Brain Conditions Benefit When Guard is Down
Monday, November 17th, 2008
The blood-brain barrier is a powerfulguard that lets nutrients in while keeping foreign matter out.
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The blood-brain barrier is a powerfulguard that lets nutrients in while keeping foreign matter out.
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Reuters - Medicare, the U.S. government’s largest payer of health care, said on Monday it does not plan to cover weight-loss surgery in diabetic patients who are not dangerously overweight, saying there is not enough evidence to show it can improve their health.
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Background:Regionalization of adult critical care services may improve outcomes for critically ill patients. We sought to develop a framework for understanding clinician attitudes toward regionalization and potential barriers to developing a tiered, regionalized system of care in the United States.Methods:We performed a qualitative study using semi-structured interviews of critical care stakeholders in the United States, including physicians, nurses and hospital administrators. Stakeholders were identified from a stratified-random sample of United States general medical and surgical hospitals. Key barriers and potential solutions were identified by performing content analysis of the interview transcriptions.Results:We interviewed 30 stakeholders from 24 different hospitals, representing a broad range of hospital locations and sizes. Key barriers to regionalization included personal and economic strain on families, loss of autonomy on the part of referring physicians and hospitals, loss of revenue on the part of referring physicians and hospitals, the potential to worsen outcomes at small hospitals by limiting services, and the potential to overwhelm large hospitals. Improving communication between destination and source hospitals, provider education, instituting voluntary objective criteria to become a designated referral center, and mechanisms to feed back patients and revenue to source hospitals were identified as potential solutions to some of these barriers.Conclusions:Regionalization efforts will be met with significant conceptual and structural barriers. These data provide a foundation for future research and can be used to inform policy decisions regarding the design and implementation of a regionalized system of critical care.
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Background:The magnetic resonance technique of arterial spin labeling (ASL) allows myocardial perfusion to be quantified without the use of a contrast agent. This study aimed to use a modified ASL technique and T1 regression algorithm, previously validated in canine models, to calculate myocardial blood flow (MBF) in normal human subjects and to compare the accuracy and repeatability of this calculation at 1.5 T and 3.0 T. A computer simulation was performed and compared with experimental findings.Results:Eight subjects were imaged, with scans at 3.0 T showing significantly higher T1 values (P < 0.001) and signal-to-noise ratios (SNR) (P < 0.002) than scans at 1.5 T. The average MBF was found to be 0.990 +/- 0.302 mL/g/min at 1.5 T and 1.058 +/- 0.187 mL/g/min at 3.0 T. The repeatability at 3.0 T was improved 43% over that at 1.5 T, although no statistically significant difference was found between the two field strengths. In the simulation, the accuracy and the repeatability of the MBF calculations were 61% and 38% higher, respectively, at 3.0 T than at 1.5 T, but no statistically significant differences were observed. There were no significant differences between the myocardial perfusion data sets obtained from the two independent observers. Additionally, there was a trend toward less variation in the perfusion data from the two observers at 3.0 T as compared to 1.5 T.Conclusions:This suggests that this ASL technique can be used, preferably at 3.0 T, to quantify myocardial perfusion in humans and with further development could be useful in the clinical setting as an alternative method of perfusion analysis.
High phosphorus levels in healthy young adults increase the risk of developing coronary artery atherosclerosis many years later, according to research published online Nov. 5 in the Journal of the American Society of Nephrology.
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Substantial inequalities in healthy life years (HLYs) from the age of 50 years exist in the 25 countries of the European Union (EU). The higher a country’s gross domestic product (GDP) and spending on elderly care, the more HLYs a person at 50 can expect to live. And the EU target of having the employment rate of older workers (55-64 years) at 50% by 2010 is unlikely to be achieved in some countries unless there are substantial health improvements.
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Medicare pays for screening with flexible sigmoidoscopy once every 48 months for beneficiaries who have attained age 50.
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HealthDay - MONDAY, Nov. 17 (HealthDay News) — How you live affects your chances of developing cancer after age 65, new research finds.
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One of the least-appreciated advances in pediatric rheumatology over the past 25 years has been the delineation of the many ways in which children with rheumatic disease differ from adults with the same illnesses. Furthermore, we are now learning that paradigms that are useful in evaluating adults with musculoskeletal complaints have limited utility in children. Nowhere is that more true than in the use of commonly used laboratory tests, particularly antinuclear antibody (ANA) and rheumatoid factor (RF) assays. This short review will provide the practitioner with the evidence base that supports a more limited use of ANA and RF testing in children.
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Background:Throughout the period of one year, approximately 50% of recreational runners will sustain an injury that disrupts their training regimen. Foot orthoses have been shown to be clinically effective in the prevention and treatment of several common running injuries, yet the physical effect of this intervention during running remains poorly understood. The aim of this literature review was to evaluate the biomechanical trials in which the effect of foot orthoses on lower extremity forces and pressure (kinetics) was investigated. Methods:A systematic search of electronic databases including Medline (1966-present), CINAHL, SportDiscus, and The Cochrane Library occurred on 7 May 2008. Eligible articles were selected according to pre-determined criteria. Methodological quality was evaluated by use of the Quality Index as described by Downs & Black, followed by critical analysis according to outcome variables. Results:The most widely reported kinetic outcomes were loading rate and impact force, however the effect of foot orthoses on these variables remains unclear due to inconsistent findings. In contrast, current evidence suggests that a reduction in the rearfoot inversion moment is the most consistent kinetic effect of foot orthoses during running. Conclusions:The findings of this review demonstrate systematic effects that can be used to inform the direction of future research in this field, as further evidence is required to adequately define the mechanism of action of foot orthoses during running. Continuation of research in this field will enable targeting of design parameters towards biomechanical variables that are supported by evidence, and may lead to advancements in clinical efficacy.
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