Assisted Living Community Guide

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The mechanistic prodding and probing of ?-secretase would be much easier if only one could plainly see the thing…

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US researchers examining how diseases in late life, such as stroke and diabetes, contribute to cognitive decline through their effect on the hippocampal region of the brain found that high blood sugar may contribute to the decline of memory and cognitive health in older people. They suggested exercising to improve blood sugar levels was a way some people might be able to delay the normal decline in memory and cognitive health that occurs in old age.

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People with a sleep disorder that causes them to kick or cry out during their sleep may be at greater risk of developing dementia or Parkinson’s disease, according to a study published in the December 24, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. The sleep disorder is called REM sleep behavior disorder.

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Common variants in a serine/threonine kinase gene — STK39 — which regulates the kidneys’ excretion of salt, may be associated with an increased risk of hypertension, according to a study published online Dec. 29 in the Proceedings of the National Academy of Sciences Early Edition

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Some elements of patient-reported health-related quality of life from patients with cystic fibrosis can help predict their survival, according to research published in the Jan. 1 issue of the American Journal of Respiratory and Critical Care Medicine.

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Newly diagnosed heart failure develops in approximately three-quarters of elderly patients within the first five years after their initial myocardial infarction, according to a report published in the Jan. 6 issue of the Journal of the American College of Cardiology.

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Mismatches between valve prostheses and patients may lead to increased late overall mortality and cardiovascular mortality, according to research published in the Jan. 6 issue of the Journal of the American College of Cardiology.

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Cancer is universally considered a disease of ageing. Today the management of elderly cancer patients poses many specific problems and it should be revisited in the light of the most recent advances in both diagnosis and treatment of human malignancies. In particular, the potential use of novel therapeutic options, based on therapeutic agents raised against molecular targets (the so called targeted therapy), appears to be promising in this clinical settings especially in view of the limited side-effects. The mainstays of cancer treatment during the twentieth century were surgery, radiation and chemotherapy. However, surgery is not curative in metastatic disease, radiation and chemotherapy are limited by side effects because they can’t discriminate between healthy and cancerous cells. When key molecular changes responsible for malignant transformation were identified (e.g. growth factors and their receptors), it was hoped that new targeted agents, by inhibiting cancer-specific pathways, would spare normal cells and thereby offer improved safety benefits and a higher therapeutic index over standard chemotherapeutics. The most common targeted therapies used in clinical practice, i.e. monoclonal antibodies and small molecules, are described.

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Degarelix was recently approved by the U.S. Food and Drug Administration for the treatment of advanced prostate cancer, making it the first new drug approved for this indication in the past several years, according to a Dec. 29 FDA news release.

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